The Nrf2-ARE Pathway
نویسندگان
چکیده
منابع مشابه
Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice
Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...
متن کاملThe Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight regulation is crucial to maintain cellular homeostasis. Activation of this pathway is important in preventing human diseases, such as cancer, neurodegenerative disease, cardiovascular diseases, ischemia, diabete...
متن کاملRole of the Nrf2-ARE Pathway in Liver Diseases
The liver is a central organ that performs a wide range of functions such as detoxification and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly susceptible to oxidative stress. It is well documented that liver diseases including hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are highly associated with antioxidant capacity. NF-E2-related facto...
متن کاملsquid ink polysaccharide reduces cyclophosphamide-induced testicular damage via nrf2/are activation pathway in mice
objective(s):cyclophosphamide (cp) toxicity on testis was hampered by squid ink polysaccharide (sip) via restoration of antioxidant ability in our previous investigations. this study investigated roles of nrf2/are signal pathway in testis of treated mice. materials and methods: male kunming mice were employed to undergo treatment with sip and/or cp. protein levels of nrf2, keap-1, histone deace...
متن کاملRXRa Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negatively controlled. Here, we report that retinoic X receptor alpha (RXRa) is a hith...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2008
ISSN: 0077-8923
DOI: 10.1196/annals.1427.036